Mesotherapy and Phosphatidylcholine Injections: Historical Clarification and Review

@article{Rotunda2006MesotherapyAP,
  title={Mesotherapy and Phosphatidylcholine Injections: Historical Clarification and Review},
  author={Adam M. Rotunda and Michael S. Kolodney},
  journal={Dermatologic Surgery},
  year={2006},
  volume={32},
  pages={465–480}
}
BACKGROUND Mesotherapy was originally conceived in Europe as a method of utilizing cutaneous injections containing a mixture of compounds for the treatment of local medical and cosmetic conditions. [...] Key MethodMETHODS A comprehensive search of Medline indexed literature and conference proceedings. RESULTS All the published studies evaluating the clinical efficacy of traditional mesotherapy currently originate from Europe. These reports focus primarily on musculoskeletal pain and vascular disease, rather…Expand
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TLDR
A bibliographical review was conducted and it was verified the need for new studies with adequate methods to confirm the benefits of intradermotherapy as used in dermatologic treatment. Expand
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TLDR
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  • Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
  • 2011
TLDR
Mesotherapy is a well-tolerated and effective alternative treatment modality for reducing the diameter of body circumference and no patient showed irregularities, dimples or any serious side effects after treatment. Expand
Factitious thyrotoxicosis induced by mesotherapy: a case report.
TLDR
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TLDR
It is demonstrated that mesotherapy with PC and DC affects the subcutaneous fat, and it is theorize that the reduction of sub cutaneous fat likely follows inflammatory‐mediated necrosis and resorption. Expand
Cellulite: Is there a role for injectables?
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Until further studies are performed, patients considering mesotherapy for cellulite must be aware that the substances currently being injected to treat this cosmetically disturbing, but medically benign, condition have not been thoroughly evaluated for safety or efficacy. Expand
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A new side effect consisting of an urticaria-pigmentosa-like eruption located at the sites of the injections is reported, commonly reported in patients with asymptomatic red brownish macules with moderate pruritus. Expand
Mesotherapy for Body Contouring
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The use of mesotherapy for body contouring, spot weight loss, and overall weight reduction typically involves multiple injections of phosphatidylcholine (lecithin) into the area selected for contouring. Expand
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TLDR
A 27-year-old woman who had been treated with seven sessions of mesotherapy once or twice a week to reduce localized abdominal subcutaneous fat (cellulite) noticed several erythematous tender nodules at the injection sites of the abdomen, but after 4 weeks, however, the nodules showed liquefaction, fat necrosis with ulceration, and yellowish serous discharge. Expand
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TLDR
Three women, aged 24, 27 and 44 years, presented with similar clinical features, consisting of painful nodules located at the points where mesotherapy had been applied, and a multidrug long-term regimen was needed to achieve resolution of the lesions. Expand
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The clinical experience supports laboratory investigations demonstrating that deoxycholate, rather than phosphatidylcholine, is the active ingredient in subcutaneously injected formulas used to treat adipose tissue, and suggests that low concentration de oxygencholate may be a relatively safe and effective treatment for small collections of fat. Expand
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TLDR
Injectable phosphatidylcholine is a novel treatment for infraorbital fat herniation that may benefit some patients who are considering blepharoplasty and larger studies evaluating long-term safety and efficacy of phosphatin-derived phospholipid for cosmetic purposes are warranted. Expand
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A major complication resulting after mesotherapy in the treatment of localized obesity is reported here. Expand
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TLDR
Clinical results reflect that phosphatidylcholine was efficacious in reducing the fatty pads in the treated areas, with few side effects, and from the authors' point of view, the off-label use of phosphatilcholine in the treatment of fatty pads and small areas of localized fat is safe, low cost, and effective. Expand
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