Mesothelial toxicity of peritoneal dialysis fluids is related primarily to glucose degradation products, not to glucose per se.

@article{Witowski2003MesothelialTO,
  title={Mesothelial toxicity of peritoneal dialysis fluids is related primarily to glucose degradation products, not to glucose per se.},
  author={Janusz Witowski and Thorsten Onno Bender and Justyna Wiśniewska-Elnur and Krzysztof Książek and Jutta Passlick-Deetjen and Andrzej K Breborowicz and A J{\"o}rres J{\"o}rres},
  journal={Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis},
  year={2003},
  volume={23 4},
  pages={381-90}
}
OBJECTIVES High concentrations of glucose and/or formation of glucose degradation products (GDPs) during heat sterilization of peritoneal dialysis fluids (PDFs) are believed to be key factors in the limited biocompatibility of PDFs. We have previously shown that several identified GDPs can specifically impair human peritoneal mesothelial cell (HPMC) function. In the present study we aimed at differentiating the respective roles of glucose and GDPs in the toxicity of PDF to mesothelial cells… CONTINUE READING