Mesothelial cells differentiate into fibroblast-like cells under the scirrhous gastric cancer microenvironment and promote peritoneal carcinomatosis in vitro and in vivo

@article{Lv2013MesothelialCD,
  title={Mesothelial cells differentiate into fibroblast-like cells under the scirrhous gastric cancer microenvironment and promote peritoneal carcinomatosis in vitro and in vivo},
  author={Zhi-Dong Lv and Hai-Bo Wang and Qian Dong and Bin Kong and Jian-guo Li and Zhao-Chuan Yang and Hui-Li Qu and Wei-hong Cao and Huimian Xu},
  journal={Molecular and Cellular Biochemistry},
  year={2013},
  volume={377},
  pages={177-185}
}
Peritoneal metastases are one reason for the poor prognosis of scirrhous gastric cancer (SGC), and myofibroblast provides a favorable environment for the peritoneal dissemination of gastric cancer. The aim of this study was to determine whether myofibroblast originates from peritoneal mesothelial cells under the influence of the tumor microenvironment. Immunohistochemical studies of peritoneal biopsy specimens from patients with peritoneal lavage cytological (+) status demonstrate the… CONTINUE READING
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