Mesoscopic models of neurotransmission as intermediates between disease simulators and tools for discovering design principles.

@article{Voit2012MesoscopicMO,
  title={Mesoscopic models of neurotransmission as intermediates between disease simulators and tools for discovering design principles.},
  author={Eberhard O. Voit and Zhen Qi and Senichiro Kikuchi},
  journal={Pharmacopsychiatry},
  year={2012},
  volume={45 Suppl 1},
  pages={
          S22-30
        }
}
Two grand challenges have been declared as premier goals of computational systems biology. The first is the discovery of network motifs and design principles that help us understand and rationalize why biological systems are organized in the manner we encounter them rather than in a different fashion. The second goal is the development of computational models supporting the investigation of complex systems, in particular, as simulation platforms in personalized medicine and predictive health… CONTINUE READING

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