Mesoscale porous silica as drug delivery vehicles: Synthesis, characterization, and pH-sensitive release profiles

@inproceedings{Demuth2011MesoscalePS,
  title={Mesoscale porous silica as drug delivery vehicles: Synthesis, characterization, and pH-sensitive release profiles},
  author={Peter Demuth and Matthew T. Hurley and Chunwei Wu and Stephanie Galanie and Michael R Zachariah and Philip DeShong},
  year={2011}
}
Abstract Mesoporous silica nanoparticles (MSN) have potential as drug delivery and controlled release devices due to their high surface area and absorption capabilities. The effect of surface charge and pH on the release of the fluorescent dye, rhodamine 6G, from MSN has been studied. Release profiles of rhodamine 6G from bare and amine-coated MSN at pH 5.0 and 7.4 are very different and demonstrate that electrostatic interactions between entrapped rhodamine 6G molecules and the charged surface… CONTINUE READING

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