Mesoscale physical principles of collective cell organization

@article{Trepat2018MesoscalePP,
  title={Mesoscale physical principles of collective cell organization},
  author={X. Trepat and E. Sahai},
  journal={Nature Physics},
  year={2018},
  volume={14},
  pages={671-682}
}
We review recent evidence showing that cell and tissue dynamics are governed by mesoscale physical principles. These principles can be understood in terms of simple state diagrams in which control variables include force, density, shape, adhesion and self-propulsion. An appropriate combination of these physical quantities gives rise to emergent phenomena such as cell jamming, topological defects and underdamped waves. Mesoscale physical properties of cell assemblies are found to precede and… Expand
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References

SHOWING 1-10 OF 136 REFERENCES
Mechanobiology of collective cell behaviours
TLDR
This work has shown that the physical properties of the cellular environment, which include matrix stiffness, topography, geometry and the application of external forces, can alter collective cell behaviours, tissue organization and cell-generated forces. Expand
Motility-driven glass and jamming transitions in biological tissues.
TLDR
A self-propelled Voronoi (SPV) model is studied that simultaneously captures polarized cell motility and multi-body cell-cell interactions in a confluent tissue, where there are no gaps between cells, and precisely captures a jamming transition from a solid-like state to a fluid- like state. Expand
Flocking transitions in confluent tissues.
TLDR
This model examines a self-propelled Voronoi (SPV) model of confluent tissues with an orientational feedback that aligns a cell's polarization with its local migration velocity and finds that aligning interactions facilitate collective motion and promote solidification. Expand
Plithotaxis and emergent dynamics in collective cellular migration.
TLDR
In a broad range of epithelial and endothelial cell sheets, collective cell migration is governed instead by a newly discovered emergent mechanism of innately collective cell guidance - plithotaxis. Expand
Emergent structures and dynamics of cell colonies by contact inhibition of locomotion
TLDR
The prominent role of CIL is highlighted in determining the emergent structures and dynamics of cell colonies by means of simulations of self-propelled particles with generic cell-like interactions. Expand
Emergence of collective modes and tri-dimensional structures from epithelial confinement.
TLDR
It is demonstrated that epithelial confinement alone can induce morphogenesis-like processes including spontaneous collective pulsations and transition from 2D to 3D. Expand
Force percolation of contractile active gels.
TLDR
A state diagram is proposed that unites a large body of experimental observations on contractile active gels composed of actin filaments and myosin motors and provides valuable insights into the mechanisms that drive cellular shape changes and also provides design principles for synthetic active materials. Expand
Scaling the microrheology of living cells.
TLDR
A scaling law is reported that governs both the elastic and frictional properties of a wide variety of living cell types, over a wide range of time scales and under a variety of biological interventions, and implies that cytoskeletal proteins may regulate cell mechanical properties mainly by modulating the effective noise temperature of the matrix. Expand
Collective cell guidance by cooperative intercellular forces
TLDR
Migrations of both endothelial and epithelial monolayers conform to this behavior, as do breast cancer cell lines before but not after the epithelial-mesenchymal transition, and collective migration in these diverse systems is seen to be governed by a simple but unifying physiological principle. Expand
The Influence of Cell Mechanics, Cell-Cell Interactions, and Proliferation on Epithelial Packing
TLDR
A vertex model is used for the epithelial junctional network in which cell packing geometries correspond to stable and stationary network configurations and accounts qualitatively and quantitatively for the observed packing geometry in the wing disc and its response to perturbation by laser ablation. Expand
...
1
2
3
4
5
...