Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers.

@article{Popat2011MesoporousSN,
  title={Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers.},
  author={Amirali Popat and Sandy Budi Hartono and Frances Stahr and Jian Liu and Shi Zhang Qiao and Gao Qing Max Qing Max Lu},
  journal={Nanoscale},
  year={2011},
  volume={3 7},
  pages={
          2801-18
        }
}
Mesoporous silica nanoparticles (MSNs) provide a non-invasive and biocompatible delivery platform for a broad range of applications in therapeutics, pharmaceuticals and diagnosis. The creation of smart, stimuli-responsive systems that respond to subtle changes in the local cellular environment are likely to yield long term solutions to many of the current drug/gene/DNA/RNA delivery problems. In addition, MSNs have proven to be promising supports for enzyme immobilisation, enabling the enzymes… 
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Mesoporous silica nanoparticles: Synthesis, pharmaceutical applications, biodistribution, and biosafety assessment
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The effects of various structural parameters of MSNs on protein loading, protection, and delivery performance are reviewed and enhanced stability, improved activity, responsive release, and intracellular delivery of proteins have been achieved using MSNs as delivery vehicles.
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The required features of nanofactories are discussed and an overview of current strategies for the design and fabrication of different types of nanoreactors, i.e., systems based on lipid or polymer vesicles, capsules, mesoporous silica, viral capsids, and hydrogels, and their respective advantages and shortcomings, are provided.
Stimuli responsive drug delivery application of polymer and silica in biomedicine.
TLDR
Huge progress has been made in stimuli responsive drug delivery systems based on polymer and mesoporous silica materials, mainly including pH-, thermo-, light-, enzyme-, redox-, magnetic field- and ultrasound-responsive drug Delivery systems, all of which are highlighted in this review.
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TLDR
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Porous silica nanoparticles as carrier for curcumin delivery
Mesoporous silica nanoparticles (MSN) with large surface areas and pore volumes show great potential as drug and gene carriers. However, there are still some challenging issues hinders their clinical…
Molecular confinement in fluorescent magnetic mesoporous silica nanoparticles: effect of pore size on multifunctionality.
  • Jixi Zhang, J. Rosenholm, H. Gu
  • Chemistry, Materials Science
    Chemphyschem : a European journal of chemical physics and physical chemistry
  • 2012
TLDR
The fabrication of PEG-modified FITC-labeled magnetic mesoporous silica nanoparticles is reported on to explore the effects of pore size on their magnetic relaxivity and spectroscopic properties, as well as drug-loading and -release behaviors.
Mesoporous Silica Nanoparticles as Carriers for Intracellular Delivery of Nucleic Acids and Subsequent Therapeutic Applications
TLDR
Mesoporous silica nanoparticles (MSNs or MSNPs), which are nanomaterials with excellent biocompatibility, large surface area for functionalization, and tunable pore size for encapsulating different cargos, are emerging as novel and ideal biomaterials for different biomedical applications.
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