Mesolimbic NMDA receptors are implicated in the expression of conditioned morphine reward

@article{Popik1999MesolimbicNR,
  title={Mesolimbic NMDA receptors are implicated in the expression of conditioned morphine reward},
  author={Piotr Popik and Wacław Kolasiewicz},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1999},
  volume={359},
  pages={288-294}
}
Systemic administration of a variety of N-methyl-d-aspartate (NMDA) receptor antagonists inhibits morphine’s rewarding properties in the conditioned place preference test. In this study, we investigated the anatomical loci implicated in the inhibition of expression of morphine’s reward by bilateral microinjections of a selective NMDA antagonist into the mesolimbic areas, including ventral tegmental area and nucleus accumbens. During conditioning, injections of 1 mg/kg morphine were associated… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Opioids excite dopamine neurons by hyperpolarization of local interneurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1992
View 4 Excerpts
Highly Influenced

The Rat Brain in Stereotaxic Coordinates

Trends in Neurosciences • 1984
View 1 Excerpt
Highly Influenced

Reinforcing effects of morphine microinjection into the ventral tegmental area.

Pharmacology, biochemistry, and behavior • 1980
View 4 Excerpts
Highly Influenced

Clinical medications development for opiate addiction: focus on nonopioids and opioid antagonists for the amelioration of opiate withdrawal symptoms and relapse prevention

BH Herman, CP O’Brien
Semin Neurosci • 1997
View 1 Excerpt

Similar Papers

Loading similar papers…