Mesolimbic Dopamine Signals the Value of Work

@article{Hamid2016MesolimbicDS,
  title={Mesolimbic Dopamine Signals the Value of Work},
  author={Arif A. Hamid and J. Pettibone and O. Mabrouk and V. Hetrick and R. Schmidt and Caitlin M. Vander Weele and R. Kennedy and B. Aragona and J. Berke},
  journal={Nature neuroscience},
  year={2016},
  volume={19},
  pages={117 - 126}
}
Dopamine cell firing can encode errors in reward prediction, providing a learning signal to guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating current behavior. Existing theories propose that fast (phasic) dopamine fluctuations support learning, whereas much slower (tonic) dopamine changes are involved in motivation. We examined dopamine release in the nucleus accumbens across multiple time scales, using complementary microdialysis and voltammetric methods… Expand
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