Mesolimbic 7-OH-DPAT affects locomotor activities in rats

  title={Mesolimbic 7-OH-DPAT affects locomotor activities in rats},
  author={Merle E. Meyer},
  journal={Pharmacology Biochemistry and Behavior},
  • M. E. Meyer
  • Published 1 October 1996
  • Biology, Psychology
  • Pharmacology Biochemistry and Behavior
Locomotor hypoactivity and motor disturbances--behavioral effects induced by intracerebellar microinjections of dopaminergic DA-D2/D3 receptor agonists.
Preliminary results seem to indicate that bilateral injection of 7-OH-DPAT, a DA-D2/D3 receptor agonist, to lobule 9/10 of rat cerebellar cortex reduces spontaneous locomotor activity (hypolocomotor effects) and induces balance and motor coordination disturbances, respectively.
Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol and clozapine.
The results of the study indicate that nafadotride, the dopamine D3 receptor antagonist, has a behavioral and biochemical profile of action different from that of haloperidol but partially similar to that of clozapine.
Effects of AMPA/kainate receptor blockade on responses to dopamine receptor agonists in the core and shell of the rat nucleus accumbens
The present results demonstrate differential interactions of AMPA receptor blockade with dopamine agonists in ”dopamine-intact” animals and lack of site-selective effects of (+)-SKF-38393 and of 7-OH-DPAT within NAS is not attributable to drug diffusion.
The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats
The facilitatory influence of a “high” dose of PD128,907 upon locomotion is mediated by postsynaptic D2 receptors and, possibly, countered by their D3 counterparts, while selective blockade of D2 but not of D3 receptors alone suppresses motor function.
Role of dopamine D2-like receptors and their modulation by adenosine receptor stimulation in the reinstatement of methamphetamine seeking
These results demonstrate the sufficiency of dopamine D3 receptors to reinstate MA seeking that is inhibited when combined with adenosine A1 receptor stimulation.
NMDA or AMPA/kainate receptor blockade prevents acquisition of conditioned place preference induced by D2/3 dopamine receptor stimulation in rats
Acquisition of place conditioning induced by systemic administration of 7-OH-DPAT is blocked by systemic NMDA receptor antagonism by MK-801 or by the AMPA/kainate receptor antagonist NBQX microinjected into the NAS shell subregion.
Dopamine receptor subtypes and ingestive behaviour.
7-OH-DPAT reduced successive negative contrast leading to the proposal that D3 receptors may mediate relative as well as absolute reinforcer value, and may well have implications for the treatment of eating disorders.


Locomotor activity following intra‐accumbens microinjections of dopamine D1 agonist SK&F 38393 in rats
The data were supportive of the hypothesis that dose‐related locomotor activities elicited by microinjections of SK&F 38393 into the Acb are independently mediated by D1 receptors.
Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.
Three dopamine receptor agonists had affinities for binding to the D-3 receptor that correlated highly with their relative potencies in decreasing cocaine self-administration in the rat at doses that were not by themselves reinforcing.
Biochemical and electrophysiological effects of 7‐OH‐DPAT on the mesolimbic dopaminergic system
The results suggest the possibility that stimulation of dopamine D2 receptors with 7‐OH‐DPAT mimic biochemical and electrophysiological actions previously ascribed to D2 autoreceptor stimulation; however the lack of selective D3 antagonist precludes any firm conclusion in this sense.
Dissociation of autoreceptor activation and behavioral consequences of low-dose apomorphine treatment
  • M. R. Lynch
  • Biology, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1991