Mesoionic oxatriazole derivatives--a new group of NO-donors.

  title={Mesoionic oxatriazole derivatives--a new group of NO-donors.},
  author={G Karup and H Preikschat and Eric Wilhelmsen and Steen B\onlykke Pedersen and Ewa Marcinkiewicz and Katarzyna Cieślik and Ryszard Jerzy Gryglewski},
  journal={Polish journal of pharmacology},
  volume={46 6},
A number of new 3-aryl-1,2,3,4-oxatriazole-5-imine derivatives (GEA Compounds--GEAC) were synthetized. GEAC are NO-releasers as evidenced by direct measurement of NO in headspace/NO-analyzer, by cooxygenation of oxyhaemoglobin to methaemoglobin in the Werringloer's test and by generation of nitrite in the Griess' reaction. During the release of NO from GEAC the consumption of O2 could be detected only when high concentrations of GEAC were used. The mechanism of release of NO from molecules of… CONTINUE READING