Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs

@article{Sampaolesi2006MesoangioblastSC,
  title={Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs},
  author={M. Sampaolesi and S. Blot and G. D'Antona and N. Granger and R. Tonlorenzi and A. Innocenzi and P. Mognol and Jean-Lauren Thibaud and B. G{\'a}lvez and I. Barth{\'e}l{\'e}my and L. Perani and S. Mantero and M. Guttinger and O. Pansarasa and C. Rinaldi and M. D. Angelis and Y. Torrente and C. Bordignon and R. Bottinelli and G. Cossu},
  journal={Nature},
  year={2006},
  volume={444},
  pages={574-579}
}
Duchenne muscular dystrophy remains an untreatable genetic disease that severely limits motility and life expectancy in affected children. The only animal model specifically reproducing the alterations in the dystrophin gene and the full spectrum of human pathology is the golden retriever dog model. Affected animals present a single mutation in intron 6, resulting in complete absence of the dystrophin protein, and early and severe muscle degeneration with nearly complete loss of motility and… Expand
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References

SHOWING 1-10 OF 31 REFERENCES
Systemic delivery of human microdystrophin to regenerating mouse dystrophic muscle by muscle progenitor cells.
  • E. Bachrach, S. Li, +6 authors L. Kunkel
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
  • 146
  • PDF
Clinical and molecular studies in Duchenne muscular dystrophy.
  • A. Emery
  • Medicine
  • Progress in clinical and biological research
  • 1989
  • 33
...
1
2
3
4
...