Meso-dihydroguaiaretic acid isolated from Saururus chinensis inhibits cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells

@article{Moon2008MesodihydroguaiareticAI,
  title={Meso-dihydroguaiaretic acid isolated from Saururus chinensis inhibits cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells},
  author={Tae Chul Moon and Chang Seob Seo and Kyungmi Haa and Jin Cheul Kim and Nam Kyung Hwang and Tae Gyun Hong and Jee Hyeun Kim and Do Hun Kim and Jong Keun Son and Hyeun Wook Chang},
  journal={Archives of Pharmacal Research},
  year={2008},
  volume={31},
  pages={606-610}
}
Meso-dihydroguaiaretic acid (MDGA) is a medicinal herbal product isolated from the aerial parts of Saururus chinensis that inhibits the cyclooxygenase-2 (COX-2)-dependent phase of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) (IC50 9.8 μM). However, this compound did not inhibit COX-2 protein expression in BMMC at concentrations up to 30 μM, indicating that MDGA directly inhibits COX-2 activity. In addition, this compound consistently inhibited the production of… CONTINUE READING
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