Meso-diaminopimelic acid and meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD1.

@article{Uehara2006MesodiaminopimelicAA,
  title={Meso-diaminopimelic acid and meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD1.},
  author={Akiko Uehara and Yukari Fujimoto and Akiko Kawasaki and Shoichi Kusumoto and Koichi Fukase and Haruhiko Takada},
  journal={Journal of immunology},
  year={2006},
  volume={177 3},
  pages={1796-804}
}
Peptidoglycans (PGNs) are ubiquitous constituents of bacterial cell walls and exhibit various immunobiological activities. Two types of minimum essential PGN structures for immunobiological activities were chemically synthesized and designated as muramyldipeptide; N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) and gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), which are common constituents of both Gram-positive and Gram-negative bacteria, as well as most Gram-negative and some Gram-positive… CONTINUE READING

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The role of peptidoglycan in pathogenesis.

Current opinion in microbiology • 2005

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