Mesna: a novel renoprotective antioxidant in ischaemic acute renal failure.

@article{Mashiach2001MesnaAN,
  title={Mesna: a novel renoprotective antioxidant in ischaemic acute renal failure.},
  author={E Mashiach and Shifra Sela and Tali Weinstein and Hector Isaac Cohen and Shaul M. Shasha and Batya I Kristal},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2001},
  volume={16 3},
  pages={
          542-51
        }
}
BACKGROUND Reactive oxygen species (ROS) play a key role in renal ischaemia-reperfusion injury. After establishing the in vitro anti-oxidative potential of mesna, a sulfhydryl-containing compound, its effect on kidney function and morphology in a rat model of ischaemic acute renal failure (ARF) was examined. METHODS Mesna (180 mg/kg) was administered at different time points relative to ischaemia and/or reperfusion onset. Kidney function was assessed by glomerular filtration rate (GFR) and… CONTINUE READING

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