Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease

@inproceedings{PeyrinBiroulet2012MesentericFA,
  title={Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease},
  author={Laurent Peyrin-Biroulet and Florent Gonzalez and Laurent Dubuquoy and Christel Rousseaux and Caroline Dubuquoy and C{\'e}cilia Decourcelle and Alain Saudemont and Mickael Tachon and Elodie B{\'e}clin and Marie-Françoise Odou and Christel Neut and Jean Fr{\'e}d{\'e}ric Colombel and Pierre Desreumaux},
  booktitle={Gut},
  year={2012}
}
OBJECTIVE Mesenteric fat hyperplasia is a hallmark of Crohn's disease (CD), and C reactive protein (CRP) is correlated with disease activity. The authors investigated whether mesenteric adipocytes may be a source of CRP in CD and whether inflammatory and bacterial triggers may stimulate its production by adipocytes. DESIGN CRP expression in the mesenteric and subcutaneous fats of patients with CD and the correlation between CRP plasma concentrations and mesenteric messenger RNA (mRNA) levels… CONTINUE READING