Mesenchymal to epithelial transition in the human ovarian surface epithelium focusing on inclusion cysts.

@article{Okamoto2009MesenchymalTE,
  title={Mesenchymal to epithelial transition in the human ovarian surface epithelium focusing on inclusion cysts.},
  author={Sanshiro Okamoto and Aikou Okamoto and Takashi Nikaido and Misato Saito and Miho Takao and Nozomu Yanaihara and Satoshi Takakura and Kazunori Ochiai and Tadao Tanaka},
  journal={Oncology reports},
  year={2009},
  volume={21 5},
  pages={
          1209-14
        }
}
Most ovarian cancers arise from the mesothelial surface lining of the ovaries or from invaginations of this lining into the superficial ovarian cortex that form cortical inclusion cysts. Thus, these cysts are thought to be precursor lesions of ovarian carcinoma. Epithelial-mesenchymal transition, which is a transcriptional program for inducing maintenance of the mesenchymal phenotype, acts in tumor progression and metastasis. Little is known about the mechanisms involved in mesenchymal… CONTINUE READING
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Irregularly shaped inclusion cysts display increased expression of Ki67, Fas, Fas ligand, and procaspase-3 but relatively little active caspase-3.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society • 2006