Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model

@article{Borg2013MesenchymalSC,
  title={Mesenchymal stromal cells improve transplanted islet survival and islet function in a syngeneic mouse model},
  author={Danielle J. Borg and Marc Weigelt and Carmen Wilhelm and Michael Gerlach and Marc Bickle and Stephan Speier and Ezio Bonifacio and Angela Hommel},
  journal={Diabetologia},
  year={2013},
  volume={57},
  pages={522-531}
}
Islet transplantation is used therapeutically in a minority of patients with type 1 diabetes. Successful outcomes are hampered by early islet beta cell loss. The adjuvant co-transplantation of mesenchymal stromal cells (MSCs) has the promise to improve islet transplant outcome. We used a syngeneic marginal islet mass transplantation model in a mouse model of diabetes. Mice received islets or islets plus 250,000 MSCs. Kidney subcapsule, intra-hepatic and intra-ocular islet transplantation sites… CONTINUE READING