Mesenchymal stromal cells derived from umbilical cord blood migrate in response to complement C1q.

@article{Qiu2012MesenchymalSC,
  title={Mesenchymal stromal cells derived from umbilical cord blood migrate in response to complement C1q.},
  author={Yuanyuan Qiu and Leah A. Marquez-Curtis and Anna Janowska-Wieczorek},
  journal={Cytotherapy},
  year={2012},
  volume={14 3},
  pages={
          285-95
        }
}
BACKGROUND AIMS Mesenchymal stromal cells (MSC) have great potential for tissue regeneration and cellular therapy. They migrate preferentially to sites of inflammation and tissue injury, but the molecular signals that guide them to their target tissue remain to be elucidated. We have shown that complement component 1 subcomponent q (C1q) enhances the homing-related response of hematopoietic stem/progenitor cells. METHODS In this study, we investigated whether C1q elicits directional signals… CONTINUE READING
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