Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.

@article{Bartholomew2002MesenchymalSC,
  title={Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo.},
  author={Amelia M. Bartholomew and Cord Sturgeon and Mandy Siatskas and Karen T Ferrer and Kevin McIntosh and Sheila Patil and Wayne Hardy and Steve Devine and David S. Ucker and Robert F Deans and Annemarie Moseley and Ronald F. Hoffman},
  journal={Experimental hematology},
  year={2002},
  volume={30 1},
  pages={42-8}
}
OBJECTIVE Mesenchymal stem cells (MSCs), multipotential cells that reside within the bone marrow, can be induced to differentiate into various components of the marrow microenvironment, such as bone, adipose, and stromal tissues. The bone marrow microenvironment is vital to the development, differentiation, and regulation of the lymphohematopoietic system. We hypothesized that the activities of MSCs in the bone marrow microenvironment might also include immunomodulatory effects on lymphocytes… CONTINUE READING
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