Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?

@article{Teixeira2013MesenchymalSC,
  title={Mesenchymal stem cells secretome: a new paradigm for central nervous system regeneration?},
  author={F. Teixeira and M. Carvalho and N. Sousa and A. Salgado},
  journal={Cellular and Molecular Life Sciences},
  year={2013},
  volume={70},
  pages={3871-3882}
}
The low regeneration potential of the central nervous system (CNS) represents a challenge for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have been proposed as a possible therapeutic tool for CNS disorders. In addition to their differentiation potential, it is well accepted nowadays that their beneficial actions can also be mediated by their secretome. Indeed, it was already demonstrated, both in vitro and in vivo, that MSCs are able to secrete a broad range of… Expand
Exploring the secretome of mesenchymal like stem cells for central nervous system regenerative medicine: a focus on Parkinson's disease
TLDR
The scope of the present thesis was to explore the potential of the sole use of different tissue derived MSCs secretome, namely derived from bone marrow, adipose tissue and the Wharton jelly surrounding the vessels of the umbilical cord for CNS regenerative medicine, namely in PD. Expand
Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF
TLDR
It is demonstrated that application of MSCs secretome to both rat cortical and hippocampal neurons induces an increase in axonal length and this growth effect is axonal intrinsic with no contribution from the cell body. Expand
The stem cell secretome and its role in brain repair
TLDR
The most recent identification of MSC- and NPC-secreted factors, including those that are trafficked within extracellular membrane vesicles (EVs), are discussed, and their potential effects on brain repair are reflected. Expand
Differentiation of Human Mesenchymal Stem Cells towards Neuronal Lineage: Clinical Trials in Nervous System Disorders
TLDR
The potential of MSCs as a therapeutic tool to treat neurological disorders is focused on, summarizing the state of the art of this topic and the most recent clinical studies. Expand
Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation
TLDR
Data is presented indicating that the use of computer-controlled suspension bioreactors enhanced the neuroregulatory profile of hMSCs secretome, and the appropriate use of dynamic culture conditions can represent an important asset for the development of future neuro-regenerative strategies involving the use. Expand
Cell Secretome: Basic Insights and Therapeutic Opportunities for CNS Disorders
TLDR
The present review discusses the current state of the art of secretome-based therapy applications in different central nervous system (CNS) pathologies and aims to clarify some of the main questions that currently exist in the field of secretomes-based therapies and consequently gain new knowledge that may help in the clinical application ofsecretome in CNS disorders. Expand
Mesenchymal stem cells secretome as a modulator of the neurogenic niche: basic insights and therapeutic opportunities
TLDR
The use of MSCs, and their secretome, become a strong candidate to be used as a therapeutic tool for CNS applications, namely by triggering the endogenous proliferation and differentiation of neural progenitors, among other mechanisms. Expand
Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations
TLDR
Evaluating the specific impact of MSCs secretome on hippocampal proliferation and astrocyte morphology, in both WT and dnSNARE mice, demonstrated increased levels of proliferation for WT when treated with secretome. Expand
Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tissue Regeneration
TLDR
MSC-derived EVs can mimic the biological characteristics of MSCs, such as differentiation, maturation, and self-renewal, and their therapeutic potential in tissue regeneration is discussed. Expand
Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal Behavior in a Rat Model of Parkinson's Disease
TLDR
It is concluded that the use of human MSC secretome alone was able to partially revert the motor phenotype and the neuronal structure of 6‐OHDA PD animals, indicating that the human M SC secretome could represent a novel therapeutic for the treatment of PD. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 158 REFERENCES
Role of mesenchymal stem cells in neurogenesis and nervous system repair
TLDR
The potential of MSCs as candidates for use in therapies to treat neurological disorders and the molecular and cellular mechanisms by which they are understood to act are discussed. Expand
Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy
TLDR
Encouraging results indicate that MSC-MVs have similar protective and reparative properties as their cellular counterparts in tissue repair and possibly anti-cancer therapy, and represent a promising opportunity to develop novel cell-free therapy approaches that might overcome the obstacles and risks associated with the use of native or engineered stem cells. Expand
Neuroprotective features of mesenchymal stem cells.
TLDR
The targets and mechanisms of BM-MSC mediated neuroprotection are discussed, which offer significant practical advantages over other types of stem cells since they can be obtained from the adult BM and can be easily cultured and expanded in vitro under GMP conditions displaying a very low risk of malignant transformation. Expand
Mesenchymal stem cells for the treatment of neurodegenerative disease.
TLDR
MSCs transplanted into the brain have been demonstrated to promote functional recovery by producing trophic factors that induce survival and regeneration of host neurons, and proposed regenerative approaches to neurological diseases using MSCs include cell therapies in which cells are delivered via intracerebral or intrathecal injection. Expand
Mesenchymal stem cells hold promise for regenerative medicine
TLDR
The mechanisms through which MSCs exert their therapeutic potential rely on some key properties of the cells as follows: the capacity to differentiate into osteoblasts, chondrocytes, adipocytes, cardiomyocytes, hepatocytes, endothelial, and neuronal cells; the ability to secrete multiple bioactive molecules capable of stimulating the recovery of injured cells and inhibiting inflammation. Expand
Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease
TLDR
It is demonstrated that two different doses of naïve human adult mesenchymal stem cells, implanted in the striatum of rats lesioned with 6-hydroxydopamine (6-OHDA), positively survived 23 days after transplantation, and reciprocal influences between grafted cells and endogenous neural precursors could be important for the observed neurorescue effect on several brain regions. Expand
Biochemical Heterogeneity of Mesenchymal Stem Cell Populations: Clues to their Therapeutic Efficacy
TLDR
Analysis of the MSC transcriptome has led to the identification of sub populations that express a variety of regulatory proteins that function in angiogenesis, hematopoiesis, neural activities, and immunity and defense. Expand
Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases
TLDR
Evidence from preclinical studies suggested that mesenchymal stem cells, a subset of adult progenitor cells, are an effective therapy in preclinical animal models of neurological diseases, leading to the conclusion that therapeutic use of MSCs should initially focus on individuals with multiple sclerosis and persistent inflammation. Expand
Bone marrow-derived mesenchymal stem cells for the treatment of ischemic stroke
TLDR
The fundamental properties of MSCs and their potential short-term and long-term toxicities also need to be determined before moving forward to use of these cells in clinical practice. Expand
The Stem Cell Niche Should be a Key Issue for Cell Therapy in Regenerative Medicine
TLDR
The need for a deeper understanding of the identity of this cell type and its microenvironment is discussed in order to improve the effectiveness of any cell therapy for regenerative medicine. Expand
...
1
2
3
4
5
...