Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells

@article{Madec2009MesenchymalSC,
  title={Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells},
  author={A. M. Madec and Roberto Mallone and Georgia Afonso and Elham Abou Mrad and Aur{\'e}lia Mesnier and Assia Eljaafari and Charles Thivolet},
  journal={Diabetologia},
  year={2009},
  volume={52},
  pages={1391-1399}
}
Displaying immunomodulatory capacities, mesenchymal stem cells (MSCs) are considered as beneficial agents for autoimmune diseases. The aim of this study was to examine the ability of MSCs to prevent autoimmune diabetes in the NOD mouse model. Prevention of spontaneous insulitis or of diabetes was evaluated after a single i.v. injection of MSCs in 4-week-old female NOD mice, or following the co-injection of MSCs and diabetogenic T cells in irradiated male NOD recipients, respectively. The… CONTINUE READING
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