Mesenchymal stem cells promote osteosarcoma cell survival and drug resistance through activation of STAT3

@inproceedings{Tu2016MesenchymalSC,
  title={Mesenchymal stem cells promote osteosarcoma cell survival and drug resistance through activation of STAT3},
  author={Bing Tu and Jing Zhu and Shen Liu and Lei Wang and Qiming Fan and Yongqiang Hao and Cun-yi Fan and Tingting Tang},
  booktitle={Oncotarget},
  year={2016}
}
Increasing evidence suggests that the tumor microenvironment plays a key role in the development of drug resistant tumor cells. In this study, we tried to determine whether the mesenchymal stem cells (MSCs) in the tumor microenvironment contribute to the increased chemoresistance of osteosarcoma. We found that exposure of Saos-2 and U2-OS cells to MSCs conditioned medium (CM) increased the viable cells in the presence of therapeutic concentrations of doxorubicin or cisplatin. Meanwhile, the MSC… CONTINUE READING
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