Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction.

@article{Mias2009MesenchymalSC,
  title={Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction.},
  author={C{\'e}line Mias and Olivier Lairez and Elodie Trouche and J{\'e}r{\^o}me Roncalli and Denis Calise and M H S{\'e}gu{\'e}las and Catherine Ordener and Marie-Dominique Piercecchi-Marti and Nathalie Aug{\'e} and Anne Salvayre and Philippe Bourin and Angelo Parini and Daniel Cussac},
  journal={Stem cells},
  year={2009},
  volume={27 11},
  pages={2734-43}
}
Recent studies showed that mesenchymal stem cells (MSCs) transplantation significantly decreased cardiac fibrosis; however, the mechanisms involved in these effects are still poorly understood. In this work, we investigated whether the antifibrotic properties of MSCs involve the regulation of matrix metalloproteinases (MMPs) and matrix metalloproteinase endogenous inhibitor (TIMP) production by cardiac fibroblasts. In vitro experiments showed that conditioned medium from MSCs decreased… CONTINUE READING