Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor.

@article{Halpern2011MesenchymalSC,
  title={Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor.},
  author={Jennifer L. Halpern and Amy K Kilbarger and Conor C. Lynch},
  journal={Cancer letters},
  year={2011},
  volume={308 1},
  pages={91-9}
}
Bone metastasis is a common event during breast cancer progression. Recently, mesenchymal stem cells (MSCs) have been implicated in the metastasis of primary mammary cancer. Given that bone is the native environment for MSCs, we hypothesized MSCs facilitate the homing of circulating mammary cancer cells to the bone. To test this hypothesis, we examined in vitro whether bone derived MSCs from FVB mice could influence the migration of syngeneic murine mammary cancer cell lines derived from the… CONTINUE READING

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