Mesenchymal stem cells promote formation of colorectal tumors in mice.

@article{Tsai2011MesenchymalSC,
  title={Mesenchymal stem cells promote formation of colorectal tumors in mice.},
  author={Kuo-Shu Tsai and Shung-Haur Yang and Y Lei and Chih-Chien Tsai and Hsin-Wei Chen Chen and Chih-Yuan Hsu and Ling-Lan Chen and Hsei-Wei Wang and Stephanie A. Miller and Shih-Hwa Chiou and M -C Hung and S. -Y. Hung},
  journal={Gastroenterology},
  year={2011},
  volume={141 3},
  pages={1046-56}
}
BACKGROUND & AIMS Tumor-initiating cells are a subset of tumor cells with the ability to form new tumors; however, they account for less than 0.001% of the cells in colorectal or other types of tumors. Mesenchymal stem cells (MSCs) integrate into the colorectal tumor stroma; we investigated their involvement in tumor initiation. METHODS Human colorectal cancer cells, MSCs, and a mixture of both cell types were injected subcutaneously into immunodeficient mice. We compared the ability of each… CONTINUE READING
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Mesenchymal stem cell transition to tumor - associated fibroblasts contributes to fibro - vascular network expansion and tumor progression

  • M Quante, SP Tu, H Tomita
  • PLoS ONE
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