Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis

@article{Takano2014MesenchymalSC,
  title={Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis},
  author={Toshio Takano and Yin-ji Li and Akiko Kukita and Takayoshi Yamaza and Yasunori Ayukawa and Kanako Moriyama and Noritsune Uehara and Hisayuki Nomiyama and Kiyoshi Koyano and Toshio Kukita},
  journal={Laboratory Investigation},
  year={2014},
  volume={94},
  pages={286-296}
}
Mesenchymal stem cells (MSCs) have potential to differentiate into multiple cell lineages. Recently, it was shown that MSCs also have anti-inflammatory and immunomodulatory functions. In this report, we investigated the regulatory function of MSCs in the development of inflammatory bone destruction in rats with adjuvant-induced arthritis (AA rats). MSCs were isolated from rat bone marrow tissues, expanded in the presence of basic FGF, and intraperitoneally injected into AA rats. MSC… CONTINUE READING
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