Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes.

@article{Blanc2004MesenchymalSC,
  title={Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes.},
  author={K Le Blanc and Ida Rasmusson and Cecilia G{\"o}therstr{\"o}m and Cheryl Seidel and Berit Sundberg and Mikael Sundin and Kerstin Rosendahl and Charlotte Tammik and Olle Ringd{\'e}n},
  journal={Scandinavian journal of immunology},
  year={2004},
  volume={60 3},
  pages={307-15}
}
Mesenchymal stem cells (MSC) are immunomodulatory and inhibit lymphocyte proliferation. We studied surface expression of lymphocyte activation markers and secreted cytokines, when lymphocytes were activated in the presence of MSC. MSC suppressed the proliferation of phytohaemagglutinin (PHA)-stimulated CD3+, CD4+ and CD8+ lymphocytes. MSC significantly reduced the expression of activation markers CD25, CD38 and CD69 on PHA-stimulated lymphocytes. Mixed lymphocyte culture (MLC) supernatants… CONTINUE READING

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