Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population.

@article{Zhang2009MesenchymalSC,
  title={Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population.},
  author={Bin Zhang and Rui Liu and Dan Shi and Xingxia Liu and Yuan Chen and Xiaowei Dou and Xishan Zhu and Chunhua Lu and Wei Liang and Lianming Liao and Martin Zenke and Robert Chunhua Zhao},
  journal={Blood},
  year={2009},
  volume={113 1},
  pages={46-57}
}
Mesenchymal stem cells (MSCs), in addition to their multilineage differentiation, exert immunomodulatory effects on immune cells, even dendritic cells (DCs). However, whether they influence the destiny of full mature DCs (maDCs) remains controversial. Here we report that MSCs vigorously promote proliferation of maDCs, significantly reduce their expression of Ia, CD11c, CD80, CD86, and CD40 while increasing CD11b expression. Interestingly, though these phenotypes clearly suggest their skew to… CONTINUE READING
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