Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level.

@article{Jones2010MesenchymalSC,
  title={Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level.},
  author={Elena A Jones and Sarah M. Churchman and Anne A English and M H Buch and Elizabeth A. Horner and C H Burgoyne and Richard Reece and Sarah Kinsey and P T J Emery and Dennis McGonagle and Fr{\'e}d{\'e}rique Ponchel},
  journal={Annals of the rheumatic diseases},
  year={2010},
  volume={69 2},
  pages={450-7}
}
OBJECTIVE Achieving joint regeneration in rheumatoid arthritis (RA) represents a future challenge. Autologous synovial mesenchymal stem cells (MSCs) could be therapeutically exploited. However, the inflammatory milieu in the RA synovium could adversely affect endogenous MSC function. To test this hypothesis, the frequency and multipotency of RA synovial MSCs was evaluated in relation to existing synovial inflammation. METHODS Synovial inflammation was measured using the arthroscopic visual… CONTINUE READING