Mesenchymal stem cells in a polycaprolactone conduit enhance median-nerve regeneration, prevent decrease of creatine phosphokinase levels in muscle, and improve functional recovery in mice.

@article{Oliveira2010MesenchymalSC,
  title={Mesenchymal stem cells in a polycaprolactone conduit enhance median-nerve regeneration, prevent decrease of creatine phosphokinase levels in muscle, and improve functional recovery in mice.},
  author={J{\'u}lia Teixeira Oliveira and Fernanda Martins de Almeida and Adriano Biancalana and Abrah{\~a}o Fontes Baptista and Marcelo Amorim Tomaz and Paulo Assis Melo and Ana Maria Blanco Martinez},
  journal={Neuroscience},
  year={2010},
  volume={170 4},
  pages={1295-303}
}
Although the majority of peripheral-nerve regeneration studies are carried out on the sciatic nerve, lesions of the upper extremities are more common in humans and usually lead to significant physical disabilities. The present study was driven by the hypothesis that a combination of strategies, namely grafts of mesenchymal stem cells (MSC) and resorbable polycaprolactone (PCL) conduits would improve median-nerve regeneration after transection. Mouse median nerves were transected and sutured to… CONTINUE READING