Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro.

@article{Xu2004MesenchymalSC,
  title={Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro.},
  author={Wenrong Xu and Xiran Zhang and Hui Qian and Wei Zhu and Xiaochun Sun and Jiabo Hu and Hong Jian Zhou and Yong-chang Chen},
  journal={Experimental biology and medicine},
  year={2004},
  volume={229 7},
  pages={623-31}
}
A method for isolating adult human bone marrow mesenchymal stem cells (MSCs) was established, and the ability of human MSCs to differentiate into cells with characteristics of cardiomyocytes in vitro was investigated. Selected MSC surface antigens were analyzed by flow cytometry. The MSCs at Passage 2 were treated with 5-azacytidine to investigate their differentiation into cardiomyocytes. Characteristics of the putative myogenic cells were determined by immunohistochemistry and transmission… CONTINUE READING

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