Mesenchymal stem cells fail to trigger effector functions of cytotoxic T lymphocytes

@article{Rasmusson2007MesenchymalSC,
  title={Mesenchymal stem cells fail to trigger effector functions of cytotoxic T lymphocytes},
  author={Ida Rasmusson and Michael Uhlin and Katarina Le Blanc and Victor G. Levitsky},
  journal={Journal of Leukocyte Biology},
  year={2007},
  volume={82}
}
Mesenchymal stem cells (MSCs), isolated from adult human bone marrow, have immunomodulatory properties. The functional outcomes of MSCs–CTL interactions remain poorly characterized. In this study, we demonstrate that MSCs remain resistant to CTL lysis, even after pulsing with the specific synthetic peptide at high concentrations, in spite of surface expression of the relevant MHC class I allele. MSCs were also much less sensitive to lysis by an allo‐specific CTL clone as compared with HLA… 

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...

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