Mesenchymal stem cells enhance the induction of mixed chimerism and tolerance to rat hind-limb allografts after bone marrow transplantation.

@article{Pan2010MesenchymalSC,
  title={Mesenchymal stem cells enhance the induction of mixed chimerism and tolerance to rat hind-limb allografts after bone marrow transplantation.},
  author={Hua Pan and K. Zhao and Lu Wang and Yan Zheng and Guoyou Zhang and Haixing Mai and Yan Han and Li Yang and Shuzhong Guo},
  journal={The Journal of surgical research},
  year={2010},
  volume={160 2},
  pages={315-24}
}
BACKGROUND Mixed hematopoietic chimerism via bone marrow transplantation has been shown to induce donor specific tolerance to solid organ allografts, but graft versus host disease (GVHD) remains to be a risk. Composite tissue allografts may need a higher percentage of donor chimerism compared with less immunogenic solid organ allografts. In this study, we investigated the potential of mesenchymal stem cells (MSCs) in the induction of stable and high level chimerism and subsequent donor-specific… CONTINUE READING

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