Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models.

@article{Shin2014MesenchymalSC,
  title={Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models.},
  author={Jin Young Shin and Hyun Jung Park and Ha Na Kim and Se Hee Oh and Jae-Sung Bae and Hee-Jin Ha and Phil Hyu Lee},
  journal={Autophagy},
  year={2014},
  volume={10 1},
  pages={
          32-44
        }
}
Current evidence suggests a central role for autophagy in Alzheimer disease (AD), and dysfunction in the autophagic system may lead to amyloid-β (Aβ) accumulation. Using in vitro and in vivo AD models, the present study investigated whether mesenchymal stem cells (MSCs) could enhance autophagy and thus exert a neuroprotective effect through modulation of Aβ clearance In Aβ-treated neuronal cells, MSCs increased cellular viability and enhanced LC3-II expression compared with cells treated with A… CONTINUE READING

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