Mesenchymal stem cells decrease splenocytes apoptosis in a sepsis experimental model

  title={Mesenchymal stem cells decrease splenocytes apoptosis in a sepsis experimental model},
  author={Leonardo Pedrazza and Adroaldo Lunardelli and Carolina Luft and Carolina Uribe Cruz and Fernanda Cristina de Mesquita and Shanna Bitencourt and Fernanda Bordignon Nunes and Jarbas Rodrigues de Oliveira},
  journal={Inflammation Research},
Mesenchymal stem cells (MSCs) are potent modulators of immune responses. Sepsis is the association of a systemic inflammatory response with an infection. The aim of this study was to test the ability of MSCs derived from adipose tissue, which have immunomodulatory effects, and to inhibit the septic process in an experimental model of mice. Three experimental groups (male C57BL/6 mice) were formed for the test: control group, untreated septic group and septic group treated with MSCs (1 × 106… CONTINUE READING


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Immunomodulatory properties of mesenchymal stem cells: cytokines and factors

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