Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expression

@inproceedings{Yan2016MesenchymalSC,
  title={Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expression},
  author={Xin Yan and Yurong Cen and Qin Wang},
  booktitle={Scientific reports},
  year={2016}
}
Previous studies have demonstrated that mesenchymal stem cell (MSC) transplantation reduces the severity of collagen-induced arthritis (CIA) in mice, which is a model for rheumatoid arthritis (RA) in humans. However, the underlying molecular mechanisms remain ill-defined. Here, we showed that MSC transplantation reduced the activities of NF-κB signaling and decreased microRNA-548e (miR-548e) levels in the joint tissue in CIA-mice, seemingly through activation of transforming growth factor… CONTINUE READING
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drug-target prediction, network analysis and experimental validation

  • Zhang, Y. et al. Uncovering pharmacological mechanisms of Wu approaches
  • Scientific reports 5, 9463, doi: 10.1038…
  • 2015

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