Mesenchymal stem cells: immune evasive, not immune privileged

  title={Mesenchymal stem cells: immune evasive, not immune privileged},
  author={James A Ankrum and Joon Faii Ong and Jeffrey M. Karp},
  journal={Nature Biotechnology},
The diverse immunomodulatory properties of mesenchymal stem/stromal cells (MSCs) may be exploited for treatment of a multitude of inflammatory conditions. MSCs have long been reported to be hypoimmunogenic or 'immune privileged'; this property is thought to enable MSC transplantation across major histocompatibility barriers and the creation of off-the-shelf therapies consisting of MSCs grown in culture. However, recent studies describing generation of antibodies against and immune rejection of… CONTINUE READING