Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis

@article{Chen2017MesenchymalSC,
  title={Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis},
  author={C. Chen and D. Wang and A. Moshaverinia and D. Liu and X. Kou and Wenjing Yu and Ruili Yang and L. Sun and S. Shi},
  journal={Cell Research},
  year={2017},
  volume={27},
  pages={559-577}
}
  • C. Chen, D. Wang, +6 authors S. Shi
  • Published 2017
  • Biology, Medicine
  • Cell Research
  • Systemic sclerosis (SSc), an autoimmune disease, may cause significant osteopenia due to activation of the IL4Rα/mTOR pathway. Mesenchymal stem cell transplantation (MSCT) can ameliorate immune disorders in SSc via inducing immune tolerance. However, it is unknown whether MSCT rescues osteopenia phenotype in SSc. Here we show that MSCT can effectively ameliorate osteopenia in SSc mice by rescuing impaired lineage differentiation of the recipient bone marrow MSCs. Mechanistically, we show that… CONTINUE READING
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