Mesenchymal stem cell therapy promotes corneal allograft survival in rats by local and systemic immunomodulation.

@article{Treacy2014MesenchymalSC,
  title={Mesenchymal stem cell therapy promotes corneal allograft survival in rats by local and systemic immunomodulation.},
  author={Oliver Treacy and Lisa O'Flynn and Aideen E. Ryan and Maurice Morcos and Paul Lohan and Sabine Schu and Mieszko M Wilk and Gerry T Fahy and Matthew D Griffin and Mikhail Nosov and Thomas Ritter},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2014},
  volume={14 9},
  pages={2023-36}
}
Mesenchymal stem cells (MSCs) are being investigated extensively due to their ability to dampen immune responses. Here, we tested the ability of MSCs from three distinct sources to prolong rat corneal allograft survival. A fully allogeneic rat cornea transplant model (DA to LEW) was used. Recipient rats received 1 × 10(6) MSCs (syn [LEW], allo [DA] or third-party [Wistar Furth]) intravenously 7 days before transplantation and again on the day of transplantation (day 0). A high percentage of… CONTINUE READING