Mesenchymal stem cell therapy prevents interstitial fibrosis and tubular atrophy in a rat kidney allograft model.

@article{Franquesa2012MesenchymalSC,
  title={Mesenchymal stem cell therapy prevents interstitial fibrosis and tubular atrophy in a rat kidney allograft model.},
  author={Marcella Franquesa and Esther Pulido Herrero and Juan Torras and {\`E}lia Ripoll and Maria Flaquer and Montse Gom{\`a} and Nuria Lloberas and Ignacio Aneg{\'o}n and Josep Maria Cruzado and Josep M. Griny{\'o} and Immaculada Herrero-Fresneda},
  journal={Stem cells and development},
  year={2012},
  volume={21 17},
  pages={
          3125-35
        }
}
In solid organ transplantation, mesenchymal stem cell (MSC) therapy is strongly emerging among other cell therapies due to the positive results obtained in vitro and in vivo as an immunomodulatory agent and their potential regenerative role. We aimed at testing whether a single dose of MSCs, injected at 11 weeks after kidney transplantation for the prevention of chronic mechanisms, enhanced regeneration and provided protection against the inflammatory and fibrotic processes that finally lead to… CONTINUE READING

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