Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes

@inproceedings{Nagaishi2016MesenchymalSC,
  title={Mesenchymal stem cell therapy ameliorates diabetic nephropathy via the paracrine effect of renal trophic factors including exosomes},
  author={Kanna Nagaishi and Yuka Mizue and Takako Chikenji and Miho Otani and Masako Nakano and Naoto Konari and Mineko Fujimiya},
  booktitle={Scientific reports},
  year={2016}
}
Bone marrow-derived mesenchymal stem cells (MSCs) have contributed to the improvement of diabetic nephropathy (DN); however, the actual mediator of this effect and its role has not been characterized thoroughly. We investigated the effects of MSC therapy on DN, focusing on the paracrine effect of renal trophic factors, including exosomes secreted by MSCs. MSCs and MSC-conditioned medium (MSC-CM) as renal trophic factors were administered in parallel to high-fat diet (HFD)-induced type 2… CONTINUE READING

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