Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression.

@article{McGinley2013MesenchymalSC,
  title={Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression.},
  author={Lisa M McGinley and Jill P. McMahon and Alessia Stocca and Aoife M Duffy and Aidan Flynn and Daniel O'Toole and Timothy O'Brien},
  journal={Human gene therapy},
  year={2013},
  volume={24 10},
  pages={840-51}
}
Mesenchymal stem cell (MSC) therapy offers the potential to promote recovery after myocardial infarction (MI). However, therapeutic efficacy may be limited by poor survival and retention of transplanted cells. A combination of gene and cell therapy has the capacity to prevent donor cell death and augment the reparative and regenerative effects of cell transfer. The present study investigates the effect of exogenous heat shock protein 27 (Hsp27) expression in MSCs in an in vitro model of… CONTINUE READING

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