Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate-chitosan composite scaffold.

@article{Moreau2009MesenchymalSC,
  title={Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate-chitosan composite scaffold.},
  author={Jennifer L Moreau and Hockin H K Xu},
  journal={Biomaterials},
  year={2009},
  volume={30 14},
  pages={2675-82}
}
Calcium phosphate cement (CPC) can be molded or injected to form a scaffold in situ, has excellent osteoconductivity, and can be resorbed and replaced by new bone. However, its low strength limits CPC to non-stress-bearing repairs. Chitosan could be used to reinforce CPC, but mesenchymal stem cell (MSC) interactions with CPC-chitosan scaffold have not been examined. The objective of this study was to investigate MSC proliferation and osteogenic differentiation on high-strength CPC-chitosan… CONTINUE READING