Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide.

@article{Ren2008MesenchymalSC,
  title={Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide.},
  author={Guangwen Ren and Liying Zhang and Xin Zhao and Guangwu Xu and Yingyu Zhang and Arthur I. Roberts and Robert Chunhua Zhao and Yufang Shi},
  journal={Cell stem cell},
  year={2008},
  volume={2 2},
  pages={
          141-50
        }
}
  • Guangwen Ren, Liying Zhang, +5 authors Yufang Shi
  • Published 2008
  • Medicine, Biology
  • Cell stem cell
  • Mesenchymal stem cells (MSCs) can become potently immunosuppressive through unknown mechanisms. We found that the immunosuppressive function of MSCs is elicited by IFNgamma and the concomitant presence of any of three other proinflammatory cytokines, TNFalpha, IL-1alpha, or IL-1beta. These cytokine combinations provoke the expression of high levels of several chemokines and inducible nitric oxide synthase (iNOS) by MSCs. Chemokines drive T cell migration into proximity with MSCs, where T cell… CONTINUE READING

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    ConditionsLiver Cirrhosis
    InterventionDrug, Procedure
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    The primary purpose of the study is to evaluate the safety and efficacy of mesenchymal stem cells (MSC) for the treatment of patients who have developed an extensive chronic graft… Expand
    ConditionsChronic Graft Versus Host Disease
    InterventionBiological, Drug

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