Mesenchymal stem cell features of Ewing tumors.

  title={Mesenchymal stem cell features of Ewing tumors.},
  author={Franck Tirode and Karine Laud-Duval and Alexandre Prieur and Bruno Delorme and Pierre Charbord and Olivier Delattre},
  journal={Cancer cell},
  volume={11 5},
The cellular origin of Ewing tumor (ET), a tumor of bone or soft tissues characterized by specific fusions between EWS and ETS genes, is highly debated. Through gene expression analysis comparing ETs with a variety of normal tissues, we show that the profiles of different EWS-FLI1-silenced Ewing cell lines converge toward that of mesenchymal stem cells (MSC). Moreover, upon EWS-FLI1 silencing, two different Ewing cell lines can differentiate along the adipogenic lineage when incubated in… CONTINUE READING
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