Mesenchymal stem cell-conditioned medium improves the proliferation and migration of keratinocytes in a diabetes-like microenvironment.

@article{Li2015MesenchymalSC,
  title={Mesenchymal stem cell-conditioned medium improves the proliferation and migration of keratinocytes in a diabetes-like microenvironment.},
  author={Meirong Li and Yali Zhao and Haojie Hao and Hanren Dai and Qingwang Han and Chuan Tong and Jiejie Liu and Weidong Han and Xiaobing Fu},
  journal={The international journal of lower extremity wounds},
  year={2015},
  volume={14 1},
  pages={
          73-86
        }
}
The impairment of wound healing in diabetic patients is an important clinical problem. Proper keratinocyte migration and proliferation are the crucial steps during reepithelialization, and these steps may be impaired in diabetes mellitus (DM) due to hyperglycemia and chronic inflammation in wound site. In this study, we explored the effects of diabetes-like microenvironment with high glucose (HG) and intense inflammation on the migration and proliferation of keratinocytes in vitro. We found… CONTINUE READING
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