Mesenchymal stem cell-conditioned medium facilitates angiogenesis and fracture healing in diabetic rats.

@article{Wang2012MesenchymalSC,
  title={Mesenchymal stem cell-conditioned medium facilitates angiogenesis and fracture healing in diabetic rats.},
  author={Chien-Yuan Wang and Hsiao-Bai Yang and H A Hsu and Ling-Lan Chen and Chih-Chien Tsai and Kuo-Shu Tsai and Tu-Lai Yew and Yi-Hsuan Kao and S. -Y. Hung},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2012},
  volume={6 7},
  pages={559-69}
}
The most critical factor for fracture union is the blood supply to the fracture site, which is usually impaired in patients with diabetes. Recently, mesenchymal stem cells-derived conditioned medium (MSC-CM) has shown significantly higher levels of angiogenic factors, such as VEGF and IL-6. We demonstrate in this report that MSC-CM delivered in gelatin sponges stimulates angiogenesis and promotes fracture healing in a diabetic rat model. Subcutaneous implantation of gelatin sponges soaked in… CONTINUE READING
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