Mesenchymal stem cell carriers enhance antitumor efficacy of oncolytic adenoviruses in an immunocompetent mouse model

@inproceedings{Rincon2017MesenchymalSC,
  title={Mesenchymal stem cell carriers enhance antitumor efficacy of oncolytic adenoviruses in an immunocompetent mouse model},
  author={Esther Rincon and Teresa Cejalvo and Deepak Kanojia and Arantzazu Alfranca and Miguel {\'A}ngel Rodr{\'i}guez-Milla and Raul Andr{\'e}s Gil Hoyos and Yu Han and Lingjiao Zhang and Ramon Alemany and Maciej S. Lesniak and Javier Garc{\'i}a-Castro},
  booktitle={Oncotarget},
  year={2017}
}
Oncolytic virotherapy represents a promising alternative for cancer treatment; however, viral delivery to the tumor represents a major challenge. Mesenchymal stem cells (MSCs) chemotax to tumors, and can serve as a viral delivery tool. Previously, we demonstrated antitumor therapeutic efficacy for mesenchymal stem cells (MSCs) infected with the oncolytic human adenovirus ICOVIR5 (Celyvir) for treatment of neuroblastoma patients. Given the lack of suitable immunocompetent preclinical models, the… CONTINUE READING
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