Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts

@article{Zhu2014MesenchymalSC,
  title={Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts},
  author={Yin Zhu and Ming Cheng and Zhen Yang and Chunyan Zeng and Jiang Chen and Yong Xie and Shi-wen Luo and Kun-He Zhang and Shufeng Zhou and Nonghua Lu},
  journal={Drug Design, Development and Therapy},
  year={2014},
  volume={8},
  pages={2449 - 2462}
}
  • Yin Zhu, M. Cheng, N. Lu
  • Published 9 December 2014
  • Biology, Medicine
  • Drug Design, Development and Therapy
Mesenchymal stem cells (MSCs) have been recognized as promising delivery vehicles for gene therapy of tumors. Gastric cancer is the third leading cause of worldwide cancer mortality, and novel treatment modalities are urgently needed. NK4 is an antagonist of hepatocyte growth factor receptors (Met) which are often aberrantly activated in gastric cancer and thus represent a useful candidate for targeted therapies. This study investigated MSC-delivered NK4 gene therapy in nude mice bearing… 

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References

SHOWING 1-10 OF 89 REFERENCES

Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells

TLDR
MSC-based gene therapy did not induce the severe adverse effects induced by conventional adenoviral vectors, indicating that MSCs can serve as a vehicle of gene therapy for targeting multiple lung metastatic tumors.

Mesenchymal stem cells expressing TRAIL lead to tumour growth inhibition in an experimental lung cancer model

TLDR
This is the first study that demonstrates the potential therapeutic utility of Ad.TR‐transduced MSCs in cancer cells and the stability of this vector in the context of the blood environment.

Stem and progenitor cell-mediated tumor selective gene therapy

TLDR
It is demonstrated that neural and mesenchymal stem cells can deliver therapeutic genes to elicit a significant antitumor response in animal models of intracranial glioma, medulloblastoma, melanoma brain metastasis, disseminated neuroblastoma and breast cancer lung metastasis.

Cancer gene therapy using mesenchymal stem cells

TLDR
The potential of MSCs as cellular vehicles for targeted cancer therapy and the molecular mechanisms underlying MSC accumulation at tumor sites are reviewed.

Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival

TLDR
Peritumoral injection of Ad-NK4 plus GEM is a potent combination therapy for pancreatic cancer, and Histologic and immunohistochemical assays of primary tumors indicated that combination therapy prohibited both cell proliferation and angiogenesis, resulting in high levels of apoptosis.

VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma

TLDR
It is shown that mesenchymal stem cells supported tumour angiogenesis in vivo, that is CD31+ vessel density was increased after the transfer of MSC compared with siVEGF-MSC, and a supportive role inAngiogenesis is suggested.

Suppression of human colon tumor growth by adenoviral vector-mediated NK4 expression in an athymic mouse model.

AIM To investigate the suppressive effects of adenoviral vector-mediated expression of NK4, an antagonist of hepatocyte growth factor (HGF), on human colon cancer in an athymic mouse model to explore

TGF-β mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells.

TLDR
The TGF-β/TGFβR axis is revealed as a mediator of the tropism of BM-hMSCs for GSCs and it is suggested that T GF-β predicts patients in whom BM- hMSC delivery will be effective.
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